Correction: Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities
نویسندگان
چکیده
منابع مشابه
Conformationally restricted calpain inhibitors.
The cysteine protease calpain-I is linked to several diseases and is therefore a valuable target for inhibition. Selective inhibition of calpain-I has proved difficult as most compounds target the active site and inhibit a broad spectrum of cysteine proteases as well as other calpain isoforms. Selective inhibitors might not only be potential drugs but should act as tools to explore the physiolo...
متن کاملSynthesis and biological evaluation of conformationally restricted adenine bicycloribonucleosides.
We prepared a novel series of conformationally restricted bicyclonucleosides and nucleotides. The synthetic approach employed a ring closing metathesis to provide access to both 6 and 7 membered saturated and unsaturated rings linking the 3' to 5' methylene groups of the sugar. The bicyclonucleosides were also transformed to the corresponding phosphoramidate prodrugs by an innovative one-pot pr...
متن کاملNative-State Structural Analysis of Respiratory Syncytial Virus
Human respiratory syncytial virus (hRSV) is an enveloped RNA virus that belongs to Paramyxoviridae family. HRSV is the most common cause of bronchiolitis and pneumonia in young children in the United States, and severe infections of infants and immuno-compromised adults can lead to death. In order to characterize the molecular mechanisms underlying hRSV assembly and viral and host cellular prot...
متن کاملMolecular mechanism of respiratory syncytial virus fusion inhibitors.
Respiratory syncytial virus (RSV) is a leading cause of pneumonia and bronchiolitis in young children and the elderly. Therapeutic small molecules have been developed that bind the RSV F glycoprotein and inhibit membrane fusion, yet their binding sites and molecular mechanisms of action remain largely unknown. Here we show that these inhibitors bind to a three-fold-symmetric pocket within the c...
متن کاملRespiratory Syncytial Virus Entry Inhibitors Targeting the F Protein
Human respiratory syncytial virus (RSV) is the main viral cause of respiratory tract infection in infants as well as some elderly and high-risk adults with chronic pulmonary disease and the severely immunocompromised. So far, no specific anti-RSV therapeutics or effective anti-RSV vaccines have been reported. Only one humanized monoclonal antibody, Palivizumab, has been approved for use in high...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: MedChemComm
سال: 2018
ISSN: 2040-2503,2040-2511
DOI: 10.1039/c8md90016g